Otilonium Bromide: A Selective Spasmolytic for the Gastrointestinal Tract
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منابع مشابه
A Distribution Study with C-otilonium Bromide in the Rat: Evidence for Selective Tropism for Large Intestine after Oral Administration
The aim of this study was to determine the plasma levels and the tissue distribution of otilonium bromide, measured as total radioactivity, after oral administration of 2 mg/kg of C-labeled drug to rats. Radioactivity levels were very low in the plasma (ranging from 2.7 ng Eq/ml at 1.5 h to 0.6 ng Eq/ml at 24 h) as compared with those found in the gastrointestinal (GI) tract, indicating negligi...
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Antispasmodics are used clinically to treat a variety of gastrointestinal disorders by inhibition of smooth muscle contraction. The main pathway for smooth muscle Ca(2+) entry is through L-type channels; however, there is increasing evidence that T-type Ca(2+) channels also play a role in regulating contractility. Otilonium bromide, an antispasmodic, has previously been shown to inhibit L-type ...
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متن کاملSelective Membrane Electrode for Bromide Ion Based on Aza Pyrilium Ion Derivative as a new Ionophore.
A highly selective electrode for Bromide ion based on aza pyrilium derivative as an excellentionophore is described.The sensor exhibits a good linear response with a slope of ( 60±1 ) mV per decadeover the concentration range of ( 1×10-3 – 9×10-6 M ) , and a detection limit of ( 3×10-6 M ) of Bromideions .The electrode response is independent of pH in the range of(4.0 –9.5).Selectivity coeffici...
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ژورنال
عنوان ژورنال: Journal of International Medical Research
سال: 1999
ISSN: 0300-0605,1473-2300
DOI: 10.1177/030006059902700501